This is a viral infection caused by the herpes simplex virus (HSV). Here, we explore four common STDs that can lead to the appearance of these bumps: Or call 1-80 or start a Live Chat What STDs Cause Vaginal Bumps?Ĭertain STDs can cause vaginal bumps and lumps, which can be uncomfortable and concerning. Getting tested is not only quick and easy, it’s the only way to know for sure if you do or do not have an STD.